Athletics are an important part of the LaGrange experience. The College currently features 16 intercollegiate sports (8 for men, 8 for women) Football was added in 2006 and women’s lacrosse in 2010. The school also has a host of intramural activities. Among the best in the region, our athletic facilities include a $2 million baseball stadium, a natatorium and a softball complex.

Over one-third of on-campus students participate in athletics at LaGrange, which is a NCAA Division III member. Panther teams, with the exception of swimming, compete in the USA South Athletic Conference. The swim teams are Appalachian Swimming Conference members.

LaGrange athletic teams excelled during the 2016-17 academic year. The Panther baseball team won the USA South regular season and tournament titles, while reaching the NCAA South Regional. The baseball team finished a record-setting year 40-6 and rose to a No. 1 ranking in the Division III Top 25 polll. The Panthers had seniors Casey Bell, Ryan Broderick, and Blake Butcher named to All-America teams. Eight Panthers earned USA South All-Conference  honors, with Bell named the Player of the Year, Broaderick the Pitcher of the Year, and Richie Post as the Rookie Pitcher of the Year. 

The men's basketball team won its third USA South Tournament championship in the past four years, advancing to the NCAA Division III National Tournament for the fourth straight year. The golf team finished in the top 15 at the NCAA Division III Championships for the fourth straight year. Senior Logan Lanier was the Jack Nicklaus Award Division III Player of the Year and the recipient of the USA South Athletic Conference Don Scalf Award, given to the top male and female student-athletes in the conference. Freshman Jenna Eppes was the USA South Women's Tennis Rookie of the Year, while being named to the All-Conference first team.

LaGrange athletic teams had 127 student-athletes earn USA South Academic All-Conference recognition. The Panthers had 18 athletes earn various USA South All-Conference honors.