Athletics are an important part of the LaGrange experience. The College currently features 18 intercollegiate sports (9 for men, 9 for women). Men's lacrosse and beach volleyball will begin play during the 2019-20 academic year. Football was added in 2006 and women’s lacrosse in 2010. The school also has a host of intramural activities. Among the best in the region, our athletic facilities include a $2 million baseball stadium, a natatorium and a softball complex.

Over one-third of on-campus students participate in athletics at LaGrange, which is a NCAA Division III member. Panther teams, with the exception of swimming, compete in the USA South Athletic Conference. The swim teams are Sun Coast Swimming Conference members.

LaGrange athletic teams excelled during the 2018-19 academic year. The Panther baseball team won the USA South tournament title for the third straight year, while reaching the NCAA Birmingham Regional. Men's soccer, volleyball, men's and women's basketball, men's and women's tennis, softball, and golf all qualified for USA South Tournaments in their respective sports.

LaGrange athletic teams had 80 student-athletes earn USA South Academic All-Conference recognition. The Panthers had 24 athletes earn various USA South All-Conference honors.