Athletics are an important part of the LaGrange experience. The College currently features 16 intercollegiate sports (8 for men, 8 for women) Football was added beginning in the fall of 2006 and women’s lacrosse was added in the spring of 2010. The school also has a host of intramural activities. Among the best in the region, our athletic facilities include a $2 million baseball stadium, a natatorium and a softball complex.

Over one-third of on-campus students participate in athletics at LaGrange, which is a member of the NCAA Division III. Panther teams, with the exception of swimming, compete in the USA South Athletic Conference. The swim teams are members of the Appalachian Swimming Conference.

LaGrange athletic teams enjoyed unprecedented success during the 2014-15 academic year. Panther teams captured a school-record three USA South Tournament championships. The golf team was runner-up at the NCAA Division III national championship tournament, the highest finish by a LaGrange team in a NCAA tournament. The Panthers won their second straight USA South title, along with three other tournaments during the spring. The Panthers were led by three-time All-American Cory Howard, who was also the first LaGrange athlete to be named the USA South Player of the Year. The men's basketball team won its second straight USA South Tournament in advancing to the NCAA Division III National Tournament for the second year in a row. Senior Nick Mitchell was the conference tournament Most Valuable Player again and selected to the USA South All-Conference first team. In softball, the Panthers won their first USA South Tournament championship behind tournament MVP Dani Gravett. The Panthers made their fourth appearance in the NCAA national tournament, playing in the Atlanta Regional. The women's basketball team advanced to the semifinals of the USA South Tournament for the second straight season, as senior Shaye Butler was named to the USA South All-Conference second team.  LaGrange athletic teams had 113 student-athletes earn USA South All-Academic recognition. The Panthers had 14 athletes earn various USA South All-Conference honors.