Athletics are an important part of the LaGrange experience. The College currently features 16 intercollegiate sports (8 for men, 8 for women) Football was added beginning in the fall of 2006 and women’s lacrosse was added in the spring of 2010. The school also has a host of intramural activities. Among the best in the region, our athletic facilities include a $2 million baseball stadium, a natatorium and a softball complex.

Over one-third of on-campus students participate in athletics at LaGrange, which is a member of the NCAA Division III. Panther teams, with the exception of swimming, compete in the USA South Athletic Conference. The swim teams are members of the Appalachian Swimming Conference.

LaGrange athletic teams had a banner 2015-16 academic year. The men's basketball team advanced to the NCAA Division III National Tournament for the third straight year. The Panthers finished 20-9, the first 20-win season since the 1992-93 season. Senior Mark Wagner and junior Justyn Olson were named to the USA South All-Conference team. The golf team finished in the top 15 at the NCAA Division III Championships for the third straight year. Junior Logan Lanier was a finalist for the Division III Jack Nicklaus Award and became the second straight Panther to be selected as the USA South Golf Player of the Year. In addition, Lanier was a first team Division III PING All-American and first team USA South All-Conference. The baseball team was 30-13, tying for second in the USA South regular season standings. Junior third baseman Blake Butcher was named the USA South Baseball Player of the Year, while being named to two South Region teams. The Panthers placed nine players on the USA South All-Conference team. The women's basketball team advanced to the semifinals of the USA South Tournament for the third straight season. Senior Kelsey Mitchell and sophomore Lauren Johnson  were named to the USA South All-Conference team. LaGrange athletic teams had 158 student-athletes earn USA South All-Academic recognition. The Panthers had 19 athletes earn various USA South All-Conference honors.